Introduction Hyaluronic acid (HA) fillers are among the most widely performed minimally invasive aesthetic procedures globally, with over 6.3 million procedures performed worldwide in 2023 . While traditionally used for localized contouring, emerging large-scale data from Japan indicate a paradigm shift toward full-face, anatomy-based rejuvenation —particularly in aging populations. The study by Taichi Tamura et al. (2026) provides one of the most comprehensive real-world da

A Regenerative Medicine Perspective from the Work of Rica Tanaka The concept of anti-aging in dermatology is undergoing a paradigm shift—from superficial aesthetic modification to biological regeneration of aging tissues . Central to this transition is the role of stem cells, vascular biology, and tissue repair mechanisms . Research led by Rica Tanaka demonstrates that impaired regeneration—particularly reduced endothelial progenitor cell (EPC) function and angiogenesis—is