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The 6 Indications of Platelet-Rich Plasma in Aesthetic and Regenerative Medicine

Introduction in recent years, Platelet-Rich Plasma (PRP) has emerged as a promising autologous biological treatment modality for the use in aesthetic and regenerative medicine. Attractive features of PRP are the extended release of various growth and differentiation factors from activated platelets, tissue regenerative, and healing capabilities, as well as the lack of problems associated with immunogenicity.

This week, we would like to review 6 indications of PRP in Aesthetic and Regenerative Medicine including wound healing, skin and facial rejuvenation, hair restoration, hand rejuvenation, breast augmentation, and musculoskeletal regeneration.

1. Wound Healing

The clinical benefit of PRP as a leading treatment for healing of ulcers and wounds has been shown in numerous studies. Typically, the wound healing process is divide into four overlapping stages of haemostasis, inflammation, proliferation and remodelling or maturation. 1) Biological factors released by platelets within PRP that play crucial roles in healing processes including fibrin as a clotting agent. 2) Furthermore, PRP by reducing inflammation through suppressing cytokine secretion may improve healing, regeneration, re-epithelialization and angiogenesis of damaged and wounded tissues. 3) PRP's defensive mechanism against some bacteria in the wound site, will result in reduction of microbial infection.

2. Skin and Facial Rejuvenation

At cellular level, the most important promoter of skin ageing is decreasing the production of fibroblasts and collagen. PRP as a great source of growth factors, cytokines, and other biologically active substances associated with tissue regeneration and remodelling can be used as a safe and effective option to rejuvenate the skin. Furthermore, PRP increases the secretion of hyaluronic acid, makes skin more turgid and improves its elasticity.

3. Hand Rejuvenation

Since a few number of unpublished studies used PRP therapy for hand rejuvenation, clinical tests on PRP have shown improvement in the thickness, hydration, and softness of the hand skin after 3 or 4 months of treatment. And a combination of PRP with dermal filler could help patients to achieve the best and longer results of hand rejuvenation.

4. Breast Augmentation

Generally, there are 2 types of PRP therapy for breast augmentation procedures: 1) PRP in combination with fat transfer for breast enhancement (breast lift). This combination not only increases the size of the breast, but also significantly improves its firmness, shape and skin rejuvenation. It will also help to recover the sensitivity of the breast and nipple. 2) The use of PRP alone for breast rejuvenation purposes. This is suitable for women who are satisfied with their breast size, but would like to have better looking and youthful breasts. PRP helps the production of new tissues, collagens, and blood vessels for breast area.

5. Hair Restoration

Various scientific articles have shown that PRP therapy is an efficient option for hair loss in both men and women, which by stimulation their follicles, increase hair count, hair growth, and hair thickness. Among many types of hair loss, androgenetic alopecia, a very common type of hair loss and thinning, is the best subject to undergo PRP therapy.

6. Musculoskeletal Rejuvenation

In the USA, approximately 100 million office visits annually in orthopaedic clinics are for musculoskeletal injuries. The utilzation of PRP as an augmenter of the natural healing response has shown promising results by producing stronger bone, regenerating muscle and tendon, and increasing tissue vascularity. Great results also have been shown relief from bone pain due to accidents and traumas. In the light of the available evidence, it can be suggested that PRP can be used as a therapeutic and complementary method for musculoskeletal conditions.

In conclusion, PRP contains various bioactive proteins, growth factors, and interleukins associated with different cellular and biological process, i.e., cell proliferation, differentiation, and tissue reconstruction. The results of the studies have revealed promising evidence as an effective option.

Reference: https://onlinelibrary.wiley.com/doi/full/10.1111/exd.14074

Join Us and Learn More on PRP for Total Facial Neck & Hair Rejuvenation with #IFAAS faculty Dr Herbert Hooi in Sydney, Australia in August 2020

Hands-on Master Class

Advanced PRP (Platelet Rich Plasma) Therapy for Facial,

Neck & Hair Rejuvenation

August 10, 2020 | Sydney, Australia

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